Effect of Tiger Shrimp Shell Extract (Penaeus monodon) on Monosodium Glutamate-Induced Mice

Background: The shell is a part of the tiger shrimp (Penaeus monodon) body that often becomes waste and has not been utilized properly, but it contains secondary antioxidants can prevent oxidative stress in form astaxanthin. Although several studies have examined function astaxanthin as an antioxidant, role shells against hepar mice induced by monosodium glutamate (MSG) well knownObjective: to determine effect extract graded doses on histopathological picture hepatic MSG.Methods: Extraction was carried out with palm head oil solvent analyzed Ultraviolet-Visible spectrophotometer (UV-Vis). This study used 25 male classified into 5 groups. One group negative control without any need 4 other groups were MSG 0.84 g/kgBB. Three MSG-induced at 50 mg/kgBB, 100 200 mg/kgBB. treatment given for 35 days. Mice terminated 42nd day histopathology observed Manja Roenigk score.Results: showed better histology structure compared only MSG. Statistical tests using Kruskal Wallis test significant difference between each P value 0.005.Conclusion: Feeding damage mice.